Midfielders John Obi Mikel, Andre Schurrle and Ramires will all play no part while striker Didier Drogba is not fit enough to play for 90 minutes, according to manager Jose Mourinho.
Norwich opened the floodgates in one of three earlier kickoffs, with their new U.S. international signing Josh Sargent and Greek winger Christos Tzolis each scoring twice on their full debuts at Carrow Road.
Jose Mourinho's United side have 62 points and lead the Merseyside club by two with nine game remaining.
A player from Chilean top flight side Audax Italiano has apologised after being arrested for climbing onto a fence and kicking a spectator following a match at the weekend.
Arsenal returned to the top of the Premier League on Sunday when they beat Crystal Palace 2-0 at the Emirates Stadium with both goals scored by Alex Oxlade-Chamberlain.
Phil Foden and Riyad Mahrez scored two goals apiece as the hosts showed their impressive strength
The Belgian international has scored 13 league goals this season, four in the Champions League and four in the FA Cup, but has been criticised for not being effective against the bigger teams in England.
Manchester City moved 17 points clear of the pack with a 3-0 win at Fulham on Saturday
In a gripping title race, Liverpool showed they are ready to push Manchester City right until the final seconds of this season with their spirited 3-2 win at Newcastle United.
The ten-day-long Ganesh festival begins on September 17.
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
Images from Saturday's action in the Premier League.
Ayew strikes as Palace hold Southampton to 2-2 draw
Five talking-points from the Premier League weekend after Manchester City suffered a shock home loss to Crystal Palace, meaning that Liverpool stayed four points clear at the top following their win over Wolverhampton Wanderers.
Tottenham Hotspur secured a place in the Europa League next season as they closed out their Premier League campaign with a 1-1 draw at Crystal Palace on Sunday.
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
The points table of the English Premier League 2014-15 season.
Aaron Ramsey indulged his new goalscoring habit on his return to his boyhood club as Arsenal opened up a seven-point lead at the top of the Premier League with a 3-0 victory at Cardiff City on Saturday.
Watford climbed into the top four of the Premier League after Tom Cleverley's 92nd-minute goal gave them a 2-1 victory over Arsenal at Vicarage Road on Saturday.
Chelsea reacted angrily on Friday to newspaper reports that Carlo Ancelotti was set to replace manager Antonio Conte and that former coach Steve Holland has received texts from unhappy players who say they are missing him.
Manchester United maintained their push for a Champions League place after a Juan Mata goal on Saturday pushed Norwich City to the brink of relegation.
Liverpool's hopes of winning their first title in 24 years suffered a huge setback when they lost 2-0 at home to Chelsea and Manchester City took advantage with a 2-0 victory at Crystal Palace.
'My ancestors and my parents suffered for my generation to be free today, to work, to take the bus, to play football'
New manager David Moyes has criticised the series of fixtures Manchester United have been handed at the start of the new season, hinting it is a deliberate ploy by the Premier League to give them a tough opening.
Having spent much of his time at Chelsea operating in Eden Hazard's shadow, Willian has emerged as a leading light in the team ahead of their Champions League showdown with Barcelona.
Bruno Fernandes struck from the penalty spot in the ninth minute of stoppage time to give Manchester United victory at Brighton & Hove Albion in the Premier League on Saturday after an incredible finale.
Juergen Klopp's side will meet the winners of Sunday's other semi-final between Chelsea and Crystal Palace in the May 14th final
Manchester City were confirmed as English Premier League champions for the fifth time in six seasons on Saturday without even having to kick a ball.
Aston Villa beat Crystal Palace 1-0 to win a Premier League match for the first time since August while a late goal from Paul Dummett earned a 3-3 draw for Newcastle United against Manchester United on Tuesday.
Pogba suffered the injury in United's 3-0 Champions League win over Basel this month.
The jewel-encrusted Topkapi dagger and the enormous Spoonmaker's Diamond set amongst two more rows of diamonds were truly gape-worthy!, Letika Saran tells us after a fascinating encounter with Istanbul.
Robert Huth's double and a Riyad Mahrez goal sent Premier League leaders Leicester City six points clear after a stunning 3-1 victory at shell-shocked title rivals Manchester City on Saturday.
Following is a match by match look at the English Premier League's weekend fixtures:
Second-placed Manchester United edged closer towards qualification for the Champions League
Leicester City manager Claudio Ranieri has underscored the unpredictable nature of the Premier League this season, stating that it seemed as if "nobody wants to win the league".
Jofra Archer has passed on details of the abuse to the English Cricket Board and is seeking to have action taken.
Sergio Aguero scored five times in 20 minutes including an eight-minute hat-trick as Manchester City came from behind to thrash Newcastle United 6-1 and go back to the top of the Premier League table on Saturday.
A summary of Saturday's action in the Premier League.
Jose Mourinho made a winning return to Stamford Bridge as Chelsea beat promoted Hull City 2-0 in the Premier League on Sunday after an early Frank Lampard penalty miss.
Premier League newcomers Watford suffered a League Cup upset in a 1-0 loss at Preston North End while five-times champions Aston Villa overcame plucky Notts County 5-3 after extra-time to reach the third round on Tuesday.